Solid-liquid separations require porous filter media for the deposition of the particles in cake filtration processes. The use of woven filter media is common in discontinuous processes, where the filter cake formation is specified by parameters like the filter cake resistance and the resistance of the filter media. The resistances of filter cake and filter media cause a specific pressure drop which consequently defines the process energy effort. In many applications, to describe filter cake formation and pore clogging correctly, the particle-fluid interaction must be considered. The most precise 3D modeling approach to describe these effects is Direct Numerical Simulation (DNS) with resolved CFD-DEM coupling (Computational Fluid Dynamics coupled with the Discrete Element Method). The aim of this work is to describe solid-liquid separation processes by this numerical approach and to validate the numerical results with experimental findings...